Acid-buffering gels have been proposed for reestablishing the vaginal pH in cases of infection, trichomoniasis or menopausal atrophy. However, the efficacy of such products is not well understood.
In this study, pH buffering properties of selected products were tested by titration in vaginal fluid containing a VFS as dispersing medium. Results showed that relative buffer capacity values of the tested products were similar to those obtained in normal saline. Absolute differences were also mild.
Vaginal Infections
Bacterial vaginosis (BV) is a common sexually transmitted infection that can be embarrassing and distressing for the affected individual. It is also associated with an increased risk of HIV acquisition and transmission, pelvic inflammatory disease and adverse pregnancy outcomes [1].
Conventional treatments for BV include oral metronidazole or tinidazole; intravaginal fluconazole; and 1% gel microbicides such as dendrimer-based tinidazole. Despite these therapies, BV can recur in some women, leading to recurrent infections and a negative impact on the individual’s life and health.
Recurrent BV can occur for many reasons, including an inadequate initial treatment, failure to eradicate offending organisms or inability to restore normal vaginal microbiota. In addition to these potential causes, relapse may also occur because of persistence of pathogenic bacteria in biofilms that are more difficult to eradicate than organisms that live in free-floating cells.
Acid buffering gel has the potential to treat recurrent BV by reducing pH and maintaining normal vaginal flora in the vagina. The gel contains lactic acid and acetic acid, with glycerol added to activate the gel’s buffer system, to develop a pH of around 3.7.
Lactic acid has an excellent antimicrobial activity and is effective in preventing the recurrence of bacterial vaginosis. Similarly, acetic acid inhibits the growth of fungi that contribute to BV.
The gel can be applied to the vaginal surface as often as is appropriate for healthy women, for example twice daily in approximately regular intervals, for a period of seven days. Alternatively, the treatment regime can be repeated as soon as symptoms appear again or if bacterial vaginosis recurs.
A patented gel formulation has been developed and tested as a treatment for bacterial vaginosis. The patented gel is a polycarbophil-based formulation, with the sodium carboxymethylcellulose (SMC) as a binding agent to promote the retention of a therapeutically effective amount of the acid buffering gel on the vaginal surface.
The patented formulation is a highly stable and breathable gel that can be applied to the vaginal surface in the form of a spray or an injection. The patented gel has the potential to prevent recurrence of BV by restoring normal flora in the vagina.
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are a group of diseases that are passed from one person to another through sexual contact. These infections are more common in women than men and may cause health problems or lead to death if untreated.
These types of diseases can be caused by bacteria, fungi or viruses. STIs are very common and can affect people of all ages. They can spread during vaginal, oral, or anal sex or from a person with an STI to a partner who hasn’t had the infection.
Infections are often unnoticed and can be a source of pain, stress and embarrassment for the infected person. If not treated, buy lsd tabs online can be very serious and can cause health problems, financial burdens and emotional distress.
Some STIs are more dangerous than others, including HIV and AIDS. They can cause a variety of complications and can shorten life expectancy by several years.
Most STIs can be prevented with preventive medication, such as condoms and lubricant sprays. It is important to get tested for a STI before you start using any product.
Acid buffering gel has been shown to be a highly effective way to reduce the risk of STDs by maintaining the normal levels of vaginal pH. It also inhibits the growth of many sexually transmitted pathogens, such as herpes simplex virus type 1 (HSV-1), chlamydia trachomatis and gonorrhoeae.
Its ability to maintain the normal acidic level of the vaginal pH is thought to be a key factor in the prevention of bacterial vaginosis and other STIs. EVO100 is an investigational antimicrobial, bioadhesive gel that contains L-lactic acid and citric acid.
When applied, BufferGel combines an extremely mild acidity (pH 3.9) with a physical barrier that covers the cervical surface. This physical barrier enhances the ability of the slightly acidic BufferGel to inactivate sperm and STD pathogens.
Moreover, the mild acidity of BufferGel has been shown to inhibit the growth of harmful microbial flora in the vagina. Specifically, it inhibits the growth of Neisseria gonorrhoeae, Treponema pallidum and Haemophilus ducreyi, which are associated with gonorrhea, syphilis and bacterial vaginosis.
Menopausal Atrophy
Menopausal atrophy (also called atrophic vaginitis) is a condition where your body no longer produces enough estrogen to keep your vagina healthy and comfortable. It’s a common menopausal symptom and affects up to half of postmenopausal women.
The condition can lead to vaginal dryness and itchiness. It can also make it more likely for you to have a sexually transmitted infection.
It is important to know the difference between a vaginal atrophy (also called atrophic or hypoestrogenic vaginitis) and a yeast infection so you can get the right treatment for your condition. Both have symptoms of dryness, itching and redness but they are not the same thing.
In general, a yeast infection is caused by a fungus, while vaginal atrophy is caused by a lack of the hormone estrogen. Talk to your doctor about the different symptoms you are experiencing so you can determine which one you have.
If you are having vaginal atrophy, your doctor may recommend a prescription for acid buffering gel. This gel will help to maintain a healthy pH level in the vagina, which can reduce your risk of a vaginal infection or other issues that might occur when your body no longer produces enough estrogen.
You can also use lubricants that are specially designed to help with the discomfort of vaginal atrophy. These lubricants are usually creams or lotions that have been approved by the FDA.
Many women find these products extremely helpful. They work quickly to relieve the pain and itching of a vaginal atrophy, as well as helping to restore a normal pH balance in your body.
In addition, acid buffering gel can also help to improve your quality of life and sexual function. It can also help to make your menopausal symptoms more manageable.
Atrophic vaginitis is a very common menopausal symptom, but it’s often overlooked by many women. Unfortunately, it can be very debilitating and uncomfortable.
Atrophic vaginitis is usually triggered by the decrease in estrogen that occurs after menopause, but it can occur in younger women as well. In the long run, it can lead to a range of unpleasant symptoms and problems such as increased chances of urinary tract infections, sexual dysfunction, and postcoital bleeding.
Pregnancy
Pregnancy is a period in a woman’s life during which her body is growing a new human being, known as a fetus. In humans, pregnancy lasts about nine months, measured from the woman’s last menstrual period (LMP).
During the first trimester of pregnancy (weeks 1 to 12), a fetus grows rapidly. This is the first time it develops its brain, spinal cord and organs. It also begins to grow its heartbeat.
It is a very special time in a woman’s life, but it can be complicated by a variety of medical complications. Some of these can be prevented with proper health care, while others can be addressed with medication and lifestyle changes.
For example, a woman who has high blood pressure or diabetes is at risk for developing a preterm birth. These complications can be prevented by implementing healthy habits before and during pregnancy, such as exercise and eating a healthy diet.
Another problem faced by women during pregnancy is bacterial vaginosis (BV). BV is a vaginal infection caused by the replacement of normal lactobacillus-dominated flora with anaerobes, and results in symptomatic vulvodynia. The use of a pH-buffering gel to reduce vaginal bacteria may be an effective treatment.
This type of gel contains a water-insoluble but water-swellable cross-linked polycarboxylic acid that acts as a buffering agent to help control bacteria and maintain the correct vaginal pH. The gel is applied to the inside of the vagina, usually in a single application.
This patented technology was a big hit in the healthcare community because it was easy to administer and safe to use. Its safety was attributed to its low toxicity, non-steroidal anti-inflammatory properties and low irritation to the vaginal epithelium. In fact, it was the subject of a number of scientific studies. Some of the most notable findings include a decrease in the frequency of vulvodynia and a significant reduction in the number of follicles forming.